Yes, any Brightsign player with a serial port can send and receive commands over serial using a BrightAuthor interactive playlist or custom script. You can use the BrightSign player with controllers like Amx or Crestron. You can also use serial to turn on and off displays and interact with other devices. Visit this FAQ for more details.
Note: The DE9 serial port is fully RS-232 compatible, but the 3.5mm serial port can only interoperate with some RS-232 compatible devices. It can receive from any RS-232 device, but transmission may not work depending on the electrical characteristics of the device.